19 January 2022 – €1050 (excl. VAT)
Tuesday, 25 January 2022
Module 1: Basic toxicology and toxicological terms
What is toxicology? We will explain the relevance of toxicological knowledge and make you familiar with the most important terms in toxicology. Through examples we will define the dose response concept, including relevant dose metrics, and demonstrate how toxicity depends on exposure routes. We wrap up with an introduction to your homework assignment for module 2.
Friday, 28 January 2022
Module 2: Toxicodynamics and toxicokinetics
Review of the homework assignment. Then we proceed to explain the effects (toxicodynamics) and fate of chemical substances (toxicokinetics) in the body. This also includes a closer look at different types of effects considering toxicological mechanisms and modes of action (MoA). Brief introduction to homework for module 3.
Tuesday, 1 February 2022
Module 3: Testing and test guidelines
Review of homework task. We then describe the use of animal testing, how to get information and explain test design in the OECD test guidelines for various types of hazard testing and the principles for dose level selection. You will also learn about selection of test species, types of relevant animal examinations and how to apply a tiered approach in testing. We will touch briefly on alternative testing methods before finishing with introduction of your last homework assignment.
Friday, 4 February 2022
Module 4: Toxicological risk assessments
We go over the last homework exercise before we describe how toxicology is used in risk assessments. You will learn how to evaluate risks, for instance in connection with accidents and cases of pollution, and through examples we explain how to derive tolerable exposure levels. We also give a short introduction to Threshold of Toxicological Concern (TTC) before we wrap up the course with your final questions.